Effect of steroids and fluoropyrimidines on lymphomas. II. In vivo studies on tumor resistance and collateral sensitivity.

نویسندگان

  • J M LAMPKIN-HIBBARD
  • K L MUKHERJEE
  • C HEIDELBERGER
چکیده

Received for publication October 1, 1962. was found to be highly sensitive to 9-a-fluoro hydrocortisone (9-AFII) (fl). In 1960, a 9-AFH resistant tumor line was developed from the sub cutaneously transferred line of the lymphosarcoma (19). The effects of steroids and fluoropynimidines were studied alone and in combination on the growth of P1798 neoplasms, sensitive and resist ant to 9-AFII:, in the same host (SO, @1, @3).A number of steroids related to 9-AFH caused re gression of the tumors sensitive to 9-AFH but

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Carbon Nanotubes as Near Infrared Radiation (NIR) Molecules for Cancer treatment

Introduction: The photo-thermal therapy by nanoparticles has been recently known as an efficient strategy for the cancer treatment. Carbon nanotubes (CNTs) have been extensively studied in biomedical application due to the easy uptake and high permeability in the cells, biocompatibility in biological environments and also their unique electrical, thermal properties. They genera...

متن کامل

Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer

Objective(s): P-glycoprotein (P-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. Although siRNA delivery to reverse P-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of siRNA requires effective carriers that can deliver siRNA intracellularly with minimal toxicity on targe...

متن کامل

Induction of Resistance to Fluorodeoxyuridine Cytotoxicity and DNA Damage in Human Tumor Cells by Expression of Escherichw coli Deoxyuridinetriphosphatase'

Recent studies from our laboratory suggested that, in some human colorectal tumor cell lines, sensitivity to fluorodeoxyuridine may depend upon the extent of dUTP accumulation that occurs following drug treat ment and that elevation of dUTPase activity might be the basis for some instances of resistance to fluoropyrimidines. To test this model, we cx pressed Escherichia coil dUTPase In an estab...

متن کامل

In vivo resistance towards anthracyclines, etoposide, and cis-diamminedichloroplatinum(II).

From a single wild-type strain of Ehrlich ascites tumor, sublines resistant to daunorubicin, etoposide, and cis-diamminedichloroplatinum(II) have been developed in vivo. Different levels of resistance were achieved after 4 to 8 months for anthracyclines (greater than 32-fold), cis-diamminedichloroplatinum(II) (4-fold), and etoposide (greater than 6-fold). Anthracycline resistance was associated...

متن کامل

Large B-cell lymphoma in a dog: A cyto-histopathological evaluation and Immunophenotyping according to WHO classification for canine lymphomas

In the present study, we described cyto-histopathological features and immunophenotyping of the large B-cell lymphoma in an 8-year-old mixed breed dog with applying the World Health Organization (WHO) system of classification of canine lymphomas. In fine-needle aspiration (FNA), lymph nodes were involved by neoplastic cells of intermediate to large size with deep blue cytoplasm; consist of cent...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Cancer research

دوره 23  شماره 

صفحات  -

تاریخ انتشار 1963